This session will take an in-depth look at motor learning. The speakers will describe the evolution of motor learning research over the last few decades, review basic neural mechanisms for plasticity, and highlight current evidence for different modes of motor learning and the underlying neural substrates. Attendees will learn about the following modes of motor learning: use-dependent, strategy-based, adaptation, and reinforcement learning. Though these do not occur in isolation, suggestions for how/when to preferentially leverage different modes of motor learning in clinical practice will be discussed. The presenters will highlight current evidence supporting the application of these principles for patients with different neurologic disorders/diseases including stroke, cerebellar ataxia, spinal cord injury, and Parkinson disease.