Purpose : Neuroanatomy is historically a conventionally-taught course in the health professions curriculum. While human brain specimen dissections are an invaluable teaching tool, new iPad tablet applications allowing 3D visualization of anatomy and other novel active learning activities offer opportunities to engage students in new ways. In order to keep up with the tech-savvy students and engage them in the lab and classroom, educators must look beyond traditional lecture and lab teaching methods to engage a wide range of students with varied learning styles.Description : We introduced multiple novel active learning methods, including a 3D human anatomy application using iPad tablet technology (Visible Body¨) into the traditional physical therapy neuroanatomy lab curriculum. We distributed surveys after the end of the course to evaluate student preferences for learning and engagement. We collected demographic information, student report of use, accessibility and applicability of the iPad Visible Body¨ software, and open-ended responses to questions evaluating the specific novel methods incorporated in the course.Summary of Use : Results indicate that the iPad application supplemented learning, but lecture and lab with brain specimens ranked highest in overall course learning (63%). Students reported that active learning activities followed by lab with human brain specimens were the most engaging learning methods. When asked the open-ended question, ÒWhat was your preference for learning in the neuroanatomy lab classroom,Ó the overwhelming majority responded that they preferred a combination of lecture, real brain specimens, hands-on activities, and 3D anatomy software. When asked ÒWhich ONE lecture or lab did you feel you learned the most about neuroanatomy?Ó 81% of students responded with an active learning activity. The majority of students agreed that the iPad application Visible Body¨ should be incorporated into the course and will be applicable in other courses and clinical practice.Importance to Members: Preliminary results indicate that while traditional teaching methods still have a place in the lab and classroom, novel teaching methods that integrate technology engage students of today. We have designed a novel neuroanatomy curriculum incorporating these active learning methods and technology. We have identified advantages and limitations of the iPad technology, including potential application of this technology in other courses and clinical practice.